The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects
장윤영, Dissanayake Surangi, 윤정호, 정의원, 김창성, 박경준, 채증규, 최성호,
소속 상세정보
장윤영 ( Chang Yun-Young ) - Yonsei University College of Dentistry Department of Periodontology
( Dissanayake Surangi ) - Yonsei University College of Dentistry Department of Periodontology
윤정호 ( Yun Jeong-Ho ) - Yonsei University College of Dentistry Department of Periodontology
정의원 ( Jung Ui-Won ) - Yonsei University College of Dentistry Department of Periodontology
김창성 ( Kim Chang-Sung ) - Yonsei University College of Dentistry Department of Periodontology
박경준 ( Park Kyeong-Jun ) - YESBIO Co.
채증규 ( Chai Jung-Kiu ) - Yonsei University College of Dentistry Department of Periodontology
최성호 ( Choi Seong-Ho ) - Yonsei University College of Dentistry Department of Periodontology
KMID : 0363020110410030123
Abstract
Purpose: The purpose of this study was to determine the biological effects of cyanoacrylate-combined calcium phosphate (CCP), in particular its potential to act as a physical barrier - functioning like a membrane - in rabbit calvarial defects.
Methods: In each animal, four circular calvarial defects with a diameter of 8 mm were prepared and then filled with either nothing (control group) or one of three different experimental materials. In the experimental conditions, they were filled with CCP alone (CCP group), filled with biphasic calcium phosphate (BCP) and then covered with an absorbable collagen sponge (ACS; BCP/ACS group), or filled with BCP and then covered by CCP (BCP/CCP group).
Results: After 4 and 8 weeks of healing, new bone formation appeared to be lower in the CCP group than in the control group, but the difference was not statistically significant. In both the CCP and BCP/CCP groups, inflammatory cells could be seen after 4 and 8 weeks of healing.
Conclusions: Within the limits of this study, CCP exhibited limited osteoconductivity in rabbit calvarial defects and was histologically associated with the presence of inflammatory cells. However, CCP demonstrated its ability to stabilize graft particles and its potential as an effective defect filler in bone augmentation, if the biocompatibility and osteoconductivity of CCP were improved.
키워드
Octylcyanoacrylate; Calcium phosphate; Rabbits; Bone regeneration
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